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doi: 10.1074/jbc.M111.318410 3 NakanoTMiyamoto-MatsubaraMShoulkamyMISalemAMHPil PackSIshimiYet al

Burdon, K

In simple terms, NAD+ shuttles electrons during the reactions that turn food into ATP, the energy currency cells use to do work

KGN cells were maintained in Dulbecco's Modified Eagle Medium (DMEM, Gibco, USA) supplemented with 10% fetal bovine serum (FBS) and 1% penicillin/streptomycin at 37 C within a CO 2 incubator

Phase 1a: First-in-Human Single Ascending Dose Study (NCT02951806) Study Title: "Safety, Tolerability, and Pharmacokinetics of Single Doses of Cagrilintide in Healthy Subjects" Status: Completed Phase: Phase 1a Enrollment: 48 healthy volunteers Study Period: 2016-2017 Location: Single center (Denmark) Design: Randomized, double-blind, placebo-controlled, single ascending dose Dose Range: 0.03-10 mg SC Primary Endpoints: Safety, tolerability, PK parameters Population: Healthy male subjects, BMI 20-28 Key Results: Pharmacokinetics: Terminal half-life 5-7 days across dose range