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K.BallifB

doi: 10.1016/j.ijbiomac.2024.134229 188 ZhangH.XiangJ.FengJ.ZhangM

Its primary development target was anxiety and stress disorders, with cognitive benefits emerging as a welcome secondary effect

For instance, in a rat model of Lipopolysaccharide (LPS)-induced renal dysfunction, EC treatment significantly reduced NF-B p65 phosphorylation at Ser536 and lowered the nuclear-to-cytoplasmic p65 ratio, while preventing IB degradation, indicating its capacity to suppress NF-B activation and mitigate renal inflammation (Prince et al., 2017)