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Several studies involving older adults have reported improvements in biomarkers associated with healthy aging [10]

Other mechanisms include increased insulin sensitivity [58] and inhibiting lipogenesis [59] as well as increasing the uptake of glucose in the intestine [60] and muscles

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus (Mounjaro) and chronic weight management (Zepbound)

Interestingly, in contrast to growth hormone insensitivity (GHI), the IGF-I deficient animals are neurologically impaired, as was also reported in a single patient with a defect in the IGF-I gene[40]

Meanwhile, pharmaceutical companies depend on a system that rewards the enormous investment required to develop FDA-approved medicines otherwise they wont spend the money to develop ground breaking drugs like GLP-1s in the first place