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Familial AD is usually correlated with mutations in 3 genes encoding amyloid precursor protein (APP) and the enzymatic components of -secretase complexes, including presenilin 1 (PS1) and presenilin 2 (PS2)

Zinc ranks as the second most prevalent micronutrient in the human body, following iron, and is an integral part of more than 2500 proteins that act in the human body (Lim et al., 2013[272])