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10.1016/j.cell.2019.01.021 Cell 5 BoschG.MolemanM.BarneveldA.van WeerenP

Excessive lipid metabolic reprogramming in OA significantly raises ferroptosis risk, so targeting lipid synthesis, transport, and degradation represents a promising upstream approach to reducing ferroptotic damage

Key Takeaways Vitamin B12 is essential for red blood cell production, nervous system health, and energy metabolism, but it doesnt directly fatten you up. Current evidence suggests B12 itself is unlikely to cause weight gain

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2.4 mg was the dose advanced into Phase 3 because the efficacy/tolerability ratio peaked there