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EBioMedicine (2020) 62:103074

SAB, by activating the Nrf2 signaling pathway, shifted microglia from the M1 phenotype to the M2 phenotype, reducing neuronal damage (Zhang et al., 2017)

Dietary cuprizone-induced demyelination In this model, mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and subsequent demyelination followed by spontaneous remyelination, which is initiated during the late demyelination phase and continues robustly over the subsequent 36 weeks after withdrawal of cuprizone

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2.3 Risk factors The onset of BIPN is usually associated with factors such as the drug dosage, dosing frequency, and route of administration (Li et al., 2020)