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Extrapineal melatonin synthesis does not exhibit a circadian rhythm and it is not released into the blood but acts locally in its cell of origin and possibly in a paracrine matter on adjacent cells

6265, Supplementary Table 2)

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Microchimerism Feto-maternal microchimerism, which is the transplacental passage of semi-allogenic fetal cells to the mother or vice versa the passage of semi-allogenic maternal cells to the fetus, may trigger autoimmunity in SSc [39]