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Conclusions and hypothesis In summary, current available data indicate that Gpx4 gene is subjected to a complex transcriptional regulation that renders nuclear, cytoplasmic, and mitochondrial isoforms, but also generate an intron-retaining variant, likely corresponding to a CIRT, all derived from the same gene

(2019) 25:e12760

While not directly targeting A1 astrocytes, it may indirectly suppress their activity through neuroinflammation regulation

Effect of ginsenoside Re on the electrophysiological activity of the heart

Increased glycolytic flux feeds its branching biosynthetic pathways, including the pentose phosphate pathway (PPP) for production of ribose and cytosolic NADPH, which sustain nucleotide synthesis and antioxidant activity, respectively, as well as one-carbon metabolism for mitochondrial NADPH production and nucleotide synthesis