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In autoimmune patients, similar activation of Tregs with low dose IL-2 results in only transient activation of IL-2R signaling due to a defect in the inhibition of IL-2R desensitization, resulting in reduced pSTAT5 and DEPTOR degradation and loss of the Treg phenotype ( Figure 4 )

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Copper promotes tumorigenesis by activating the PDK1-AKT oncogenic pathway in a copper transporter 1 dependent manner

The convergent, multi-level effects of lithium and valproate on CaMKK2 activity, mRNA expression and protein abundance reveal a functional signature that indicates CaMKK2 is likely an important mediator of their mood-stabilising effects

Hypoxic regions in tumors exhibit radioresistance and may upregulate alternative metabolic enzymes, reducing the radiosensitizing effects of glycolysis blockade [130]