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Ethics statement The animal study was approved by Oujiang Laboratory Animal Ethics Committee

( a ) Co-localization of BRCA1 foci and mCherry DSB foci in U2OS-mCherry-LacI-Fok1 cells treated with the IDH1 inhibitor (IDH1i) alone or supplemented with KG, l-carnitine (l-Carn), or O-acetyl-l-carnitine (Ac-Carn) (DMSO and IDH1i, n = 26