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Complementing these pharmacological findings, genetic approaches using Hv1 knockout, knockdown, and overexpression models demonstrated that Hv1 loss attenuates NF-Bmediated cytokine production and PI3K/Akt/HIF-1dependent glycolytic reprogramming in microglia in a LPS-induced hippocampal neuroinflammation model ( Collectively, these findings emphasize Hv1 involvement in demyelinating diseases and neuroinflammation

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Lv, X.-C., Guo, W.-L., Li, L., Yu, X.-D

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It requires manufacturers to submit comprehensive clinical trial data to explicitly prove that a product is both safe and effective for a specific intended use