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GSH can modulate the activity of various redox-sensitive signaling pathways, including the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, which regulates the expression of antioxidant and detoxification genes, and the mitogen-activated protein kinase (MAPK) pathway, which regulates cell proliferation, differentiation, and apoptosis

In addition, we also collected neutrophils gene datasets with other autoinflammatory and autoimmune diseases, including systemic lupus erythematosus (SLE, GSE153781, unpublished data), adult-onset Stills disease (AOSD, GSE150996) [13], and systemic juvenile idiopathic arthritis (SJIA, GSE122552) [14] to compare the oxidative burst of neutrophils

Due to the oxidative stress placed on our bodies by normal metabolism, bad habits, bad food and bad environmental conditions, all adults should be taking supplemental dosages of antioxidants

10.1080/14728222.2021.1861249 9 BirringS

Under the influence of the crosstalk of the above factors, it will lead to increased myocardial oxygen consumption, myocardial fibrosis, increased metabolic pressure, significantly reduced cardiac efficiency and function, and ultimately DCM (Huo et al., 2021