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These pathogens possess choline TMA-lyase activity, enabling the conversion of dietary choline into trimethylamine (TMA), a precursor to TMAO, and exhibit invasive capabilities that allow them to enter and persist within vascular tissues

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22 Notably, the rate constant (510 10 9 M 1 s 1 ) of this rapid bimolecular reaction between NO and superoxide is about three to four times faster than the dismutation of superoxide by the superoxide dismutase