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[Prospects of use of research results for drugs with anitihypoxic and antioxidative properties in neuroprotective treatment strategies (opinion of the council of experts dated 26 march 2022)]

Flux along this pathway is likely to be increased under general conditions in which the mitochondrial NADH:NAD + ratio increases, which would include hypoxia and where there are deficiencies in NADH oxidation due to mitochondrial dysfunction

In experimental systems, the combination is studied as a model for examining how complementary peptide signaling pathways influence tissue remodeling and cellular repair responses