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Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection

A smaller HOMO-LUMO energy gap indicates higher molecular instability, resulting in increased reactivity, enhanced free radical scavenging capacity, and a stronger anti-oxidant effect 82

J Pineal Res 51(1):116 Galano A, Tan DX, Reiter RJ (2013) On the free radical scavenging activities of melatonins metabolites, AFMK and AMK

Comparative differences between the epigenome of healthy and diseased cell types have been widely demonstrated

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