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Chronic administration of a Ca 2+ stabilizer, dantrolene, reduced neurological symptoms of SCA3 transgenic mice [158], suggesting that mutant ATXN3-mediated dysregulation of Ca 2+ signaling plays a role in pathogenesis

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Tesamorelin acts primarily through the GHRH receptor in the anterior pituitary, while Ipamorelin selectively targets the ghrelin/growth hormone secretagogue receptor, known as GHS-R1a