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ludwiggi protects against DSS-induced colitis by enhancing the choline/7nAChR-mediated dendritic cell immune tolerance, leading to increased Foxp3 + Treg differentiation ( + dendritic cells from Enterobacter ludwiggi -treated mice exhibited higher expression of tolerogenic markers Tgfb1, Tgfb2, Aldh1a2 , and Pdl1 , and co-culture with nave CD4 + T cells enhances Treg conversion ( Enterobacter ludwiggi exhibited reduced colitis severity and expanded Treg populations in the mesenteric lymph nodes and spleen, highlighting cholines role in shaping gut-immune interactions

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The prevalence of vitamin K deficiency in chronic gastrointestinal disorders

doi: 10.1016/j.jhep.2019.04.007 83 SunKShenYXiaoXXuHZhangQLiM

In recent years, the incidence and mortality rate of AKI has been on the rise