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Briefly, we first transfer the proteins symbols to Entrez IDs based on Bioconductor annotation data package (org.Hs.eg.db/org.Mm.eg.db) and used the clusterProfiler::enrichGO or clusterProfiler::gseGO with the pvalueCutoff = 0.05, qvalueCutoff = 0.05 to do pathway enrichment analysis

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The lower availability of MOR in obese individuals may contribute to overeating as a way to compensate for reduced pleasure responses in this system