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Nonetheless, despite these limitations, our study offers significant insights into the direct impact of metformin on intestinal glucose metabolism, highlighting the role of TXNIP downregulation and GLUT1 upregulation as a key mechanism of its glucose-lowering effect

Clemmons DR, Moses AC, McKay MJ, Sommer A, Rosen DM, Ruckle J: The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity

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