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The p53 mutations exhibit dominant negative factors, leading to repression of the wild-type allele's function within the cells [54]

doi: 10.1530/jrf.0.1120243

The GPCR for secondary bile acids, GPABR1, activates the cAMP/PKA pathway, which results in the phosphorylation of the cAMP response element binding protein and binding to the CSE promoter and increased transcription of CSE