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The requirement for this metabolic reprogramming in dendritic cell activity is evidenced by studies showing that inhibition of glycolysis with 2-deoxyglucose (2-DG) or knockdown of glycolytic inducers [e.g., HIF-1 and alpha enolase (ENO1)], impaired dendritic cell maturation, and subsequent T cell activation (78, 80, 82, 83)

95% CI: 31.256.7%) [136]

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doi: 10.1016/j.mce.2005.03.007 14 WebbPNguyenPValentineCLopezGNKwokGRMcInerneyEet al

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