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What they did: A very harsh model, they ligated the inferior vena cava (vena cava inferior) in rats, which is the main channel for blood returning to the heart

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Briefly, HepG2 cells were incubated with 200 nM FLAG-tagged macrocycle for 1 h

Gene therapy studies using HGF have demonstrated beneficial effects in animal models of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and cerebral ischemia, with HGF treatment promoting neurite extension, increasing synaptogenesis, and enhancing functional recovery

Suitable pH adjusting agents or buffers include, but are not limited to acetate, bicarbonate, ammonium chloride, citrate, phosphate, pharmaceutically acceptable salts thereof, and combinations or mixtures thereof