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The expression of TXNIP was decreased in both cell lines and in both mouse intestinal and colorectal organoid membrane proteins, whereas GLUT1 levels were increased by metformin administration (Fig

Lenton KJ, et al

In the following sections of the manuscript, we emphasize the role of immunologic disturbances associated with G6PD deficiency, such as neutrophil dysfunction, impaired inflammasome activation, and disruption in the NF-B signaling pathway, which may contribute to increased ROS production, viral replication, and contagiousness in SARS-CoV-2 infection

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