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One of the mechanisms is through dietary fiber and its main fermentation product, butyrate, NF-B signaling (a key transcriptional regulator of inflammatory gene expression) suppressed by lowering IB kinase activity and increasing HDAC inhibition ( Alpha-linolenic acid found in flaxseeds, chia seeds, hemp seeds, and walnuts is used for the production of anti-inflammatory resolvins and protectins through cyclooxygenase and 15-lipoxygenase pathways, which is why it is considered an excellent contributor to the dietary omega-6 to omega-3 fatty acid ratio that deviates from the highly pro-inflammatory values characteristic of typical western diets (Table 2)

However, the specific mechanisms have been poorly understood

Consequently, with the development of synthetic biology, alternative microbial cell factories such as Saccharomyces cerevisiae (Huo et al., 2021

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