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69,70,71,72 In synergy with TNF-, IL-4 enhances the expression of vascular cell adhesion molecule-1 and P selectin on vascular endothelial cells, facilitating the trans-endothelial passage of eosinophils from the blood into the respiratory system

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The important side chain nucleophiles (in order from most to least nucleophilic) are Cys (RSH, pKa 8 \) summarizes nucleophilic addition and substitution at carbonyl carbons