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With most drugs in psychiatry, though, short half-lives do not necessarily translate into earlier benefits, and where higher levels need to be attained sooner than can be attained by waiting for 5 half-lives, this is achieved by administering higher initial (loading) doses, or by crowding earlier doses and then spacing them out into the recommended dosing intervals

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None of the mechanisms summarized here have been independently verified in adequately powered human clinical trials of 5-Amino-1MQ specifically

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Serum vitamin B12 levels show whether the patient is getting better