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In the majority of cancer types, most of the in vivo studies have shown inhibition of tumour growth (4060%) by using elevated doses of ascorbate (1-4 g/kg) either intravenously (IV) or intraperitoneally (IP) [15, 55,56,57]

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These pathological changes significantly impair the efficiency of ventilationperfusion matching, leading to a vicious cycle of restrictive ventilatory dysfunction and impaired diffusion capacity

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