glutamine glutathione depletion Reprogramming of metabolism and its impact on immune response in the tumor microenvironment | Cell Communication and Signaling Cellular Compartmentalization, Glutathione Transport and

33 Impaired activity of the folate-dependent enzyme complex in this system results in uracil being misincorporated into DNA in the place of thymine, with subsequent DNA instability

Nutrients, 15 (8), 1852

Turchi R, Tortolici F, Guidobaldi G, Iacovelli F, Falconi M, Rufini S, Faraonio R, Casagrande V, Federici M, De Angelis L, Carotti S, Francesconi M, Zingariello M, Morini S, Bernardini R, Mattei M, La Rosa P, Piemonte F, Lettieri-Barbato D, Aquilano K

For the early titration phase, consider reconstituting with a smaller amount of water

Daver NG, Garcia-Manero G, Basu S, Ravandi F, Kadia TM, Borthakur G, Jabbour E, DiNardo CD, Pemmaraju N, Brandt M, Pierce S, Hussin N, Kornblau SM, Andreeff M , Konopleva M, Ning J, Allison JP, Sharma P, Kantarjian HM