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Recent evidence has shown that systemic administration of PP-007, a CO releasing/O2 transfer agent, rescues the PI3K/HO-1 axis in CF macrophages and decreases the hyperinflammatory response to LPS, suggesting the HO-1 pathway as a potential candidate therapeutic target (107)

5 In 2021, there were 529 million people of all ages in worldwide living with diabetes, and the global age-standardized prevalence is 6.1%, which increased by 90.5% from 3.2% in 1990, and is expected to reach 9.8%, affecting 13.1 billion people

Shao H, Fu Y, Zhang P et al (2021) Transcriptome analysis of resistant and susceptible mulberry responses to Meloidogyne enterolobii infection

Supplementary material The Supplementary Material for this article can be found online at: References 1 AdamsP