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The reason is a connection most GPs still don't mention: the relationship between oestrogen, histamine and your immune system

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10.1007/s10741-021-10105-w 28

253 Grape polyphenols were also revealed to promote the expression of TJ proteins, as well as counteract the production of reactive oxygen species (ROS), mediated by LPS, and exert anti-inflammatory effects in Caco-2 cells