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The urolithin A doses used in the aforementioned mouse studies (37, 38) correspond to human-equivalent doses of approximately 14284 mg/day (for a 70-kg human, based on body surface area allometric scaling)

Blood ammonium levels in liver disease and hepatic coma

LDN works primarily by temporarily blocking opioid receptors, specifically the OGF-OGFr axis, which plays a role in the release of endorphins and enkephalins

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Furthermore, in an intracerebral hemorrhage (ICH) model, neural stem cell secretions inhibited hemin-induced ferroptosis and cerebral edema via the Nrf2 pathway, with the key component HSPE1 protein potentially mediating this protective effect [133]