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[12] Gastric acid-suppressing agents (proton-pump inhibitors and H-receptor antagonists) diminish dietary B12 liberation from protein complexes, a pharmacodynamic interaction that can exacerbate underlying deficiency

Research has documented reduced fat mass, decreased adipocyte size, and shifts in adipose tissue gene expression patterns toward fat-mobilizing rather than fat-storing phenotypes

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It is now well established that most peptide hormones and growth factors are initially synthesised as prohormones that are converted to active forms by endoproteolysis at specific sites 34