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This may also be consistent with impaired mitochondrial biogenesis as described in circulating lymphocytes in chronic inflammatory conditions (45) and in patients with idiopathic ME/CFS ( Also, we detected a reduction in serine concentration, which was inversely associated with depression and anxiety scores in LC patients

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The SIRT1 expression is decreased in the high-fat diet (HFD)-induced DKD mice model and HG-treated SV40 MES13 cells, accompanied by the increased thioredoxin-interacting protein (Txnip) expression and nuclear translocation of XBP1s (a transcription factor that binds to Txnip promoters)

4.2.4 Therapeutic potential of ferroptosis inhibitors in ICH Ferroptosis is closely linked to iron overload, impaired antioxidant defense, and lipid peroxidation in ICH, all of which contribute to inflammation and neuronal damage