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This resemblance positions them as invaluable assets in research, serving as a vital link between rodent studies and potential applications in humans

& Yan, Z

7 The Genetics of Homocycsteine Metabolism Genetic variation (polymorphism) fundamentally impacts the activities of enzymes involved in homocysteine metabolism

The critical role of the branched chain amino acids (BCAAs) Catabolism-Regulating enzymes, branched-Chain aminotransferase (BCAT) and branched-Chain -Keto acid dehydrogenase (BCKD), in human pathophysiology

Although this isoform is not directly related to drug metabolism, it is associated with liver dysfunction due to the accumulation of bile acids, which could disrupt enterohepatic recirculation and, therefore, indirectly affect drug metabolism (Zhang et al., 2015)