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doi: 10.1089/108729103771928717 39 DuPCrookTWhitenerCAlbrightPGreenawaltDZurloJ

Notably, the hypoxic environment of the periodontal pocket further synergistically upregulates TFRC by stabilizing hypoxia-inducible factor-1 (HIF-1) and enhancing the endocytosis of transferrin-bound ferric iron (Fe 3+ ) (11)