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NAC can ameliorate ribavirin therapeutic index, either by declining its toxicity or even allowing the use of a lower dose of the ribavirin, a previous report was conducted on mice illustrated that administration of NAC combined with antiviral therapy had a better response, both have a diverse mechanism of action that improves the outcome and reduce the severity of illness [71]

These dosing levels were selected according to cytotoxicity screening, which confirmed that all concentrations were within the safe range for HCoEpiC cells

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Psychiatry 225, 311320