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Description

Transient receptor potential (TRP) vanilloid 4 (TRPV4) is a member of the Ca 2+ -permeable TRP superfamily

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The interaction between interleukin-22 and interleukin-17 inhibits keratinocyte differentiation while increasing their proliferation and motility, leading to nuclear retention within the stratum corneum, epidermal hyperplasia (acanthosis), and elongation of the epidermal rete ridges (papillomatosis) all of which are characterized by psoriatic skin plaques (Becher and Pantelyushin 2012)