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Deacetylase inhibitors delay this process and thus increase NF-B activity

AST, located in the cell membrane, scavenges free radicals, preserves membrane structure, enhances immune performance, and regulates gene expression, protecting cells from oxidative damage and maintaining tissue integrity 21,22

21 , 300307 e302 (2020)

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However, it has been found that the pathological degradation of BBB hinders the proper delivery and action of therapeutic agents, due to a series of functional, structural, and biochemical changes at both the endothelial level and, consequently, in the perivascular and interstitial space [314]