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At lower doses, the increases were proportionally smaller, generally ranging from 2 to 5 beats per minute depending on the specific dose and titration schedule

doi:10.1210/jc.2019-01132 Tsai SH, Stoller ML, Sherer BA, Chao ZH, Tung TH

Researchers may examine cell behavior, structural pathway responses, inflammatory markers, and assay readouts

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In standard 7H9 media vadK , vadK:vadK His422Ala , vadK:vadK His422Asp and vadK:vadK Arg106Lys Mtb strains grew slower than the parental and complemented strains, but after 21 days incubation, there was no significant differences between the strains (Appendix Fig