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Interestingly, CUR inhibited the proliferation of gastric cancer cells by driving ferroptosis, similar to that in colorectal cancer cells, through the inhibition of the PI3K/Akt/mTOR signaling pathway (106)

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GSH is one of the most abundant thiols in mammalian cells, which can conjugate metal ions and neutralize reactive oxygen species ( in vitro and in vivo ( Accumulating evidences from animal studies showed that GSH depletion increased cisplatin nephrotoxicity but reduced cisplatin accumulation in the kidney, and in GSH-depleted rodents, induction of MT mitigates cisplatin nephrotoxicity ( In this report, we thoroughly profiled bismuths impacts on the proteome of proximal tubular cells

While headache is a very common side effect, there are people who cant tolerate this side effect especially if they need to work outside