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10.1016/S0140-6736(17)30069-7 35 LiangT.SuW.ZhangQ.LiG.GaoS.LouJ.et al (2016)

Tumor Necrosis Factor (TNF) (FasL): Fas is expressed on the surface of many cells

Notably, previous studies have revealed that transgenic overexpression of 6-PFKFB3 in mice results in notable cardiac damage, characterized by changes in heart weight-to-body weight ratio, cardiomyocyte length and increased cardiac fibrosis (51,53)