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Their ability to enhance gut integrity, support liver detoxification processes, and modulate systemic responses underscores their potential within the context of the gutliverhypothalamus axis

1) is distinct among sirtuins due to its ability to remove specific acyl post-translational modifications (PTMs), including succinylation, malonylation, and glutarylation, thereby modulating the function of both mitochondrial and cytoplasmic proteins

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