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Alkylating agent-induced toxicity and melatonin-based therapies

Excitotoxicity is a process that takes place in most neurodegenerative disorders like ALS and is related to strong NAD + depletion in neurons

Currently, no disease-modifying therapies exist for SCA3, with treatments limited to managing motor and non-motor symptoms through physiotherapy, pharmacological approaches, and speech therapy 95

What are the exact components of BDNF species (e.g., mBDNF, proBDNF and propeptide) and other cargo proteins (e.g., PCs, other neuropeptides, ATP and pH) in BDNF secretory granules that might help to fine tune the effects of released BDNF in target cells