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Iglesias E, Torrente-Segarra V, Bou R et al (2014) Non-systemic juvenile idiopathic arthritis outcome after reaching clinical remission with anti-TNF-alpha therapy: a clinical practice observational study of patients who discontinued treatment

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L-serine inhibits cGAS-STING signaling, which is involved in type I IFN production and the intratumoral infiltration of immune cells (dendritic, CD4 and CD8 T cells) 96

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These effects are diminished or lost in 3-KO mice, indicating that 3-AR signaling is essential for many, but not all, of AOD9604s actions