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The isolated effector domain exists primarily as a monomer in solution, but forms a hexamer ring in crystal via tandem association between adjacent protomers, and two hexamers are linked by the crystallographic 2-fold symmetry to generate a dodecamer [323]

Importantly, oxidative stress and glutathione deficits have also been implicated in depression, bipolar disorder, and schizophreniabroadening their potential impact across mental health care

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While small doses might be allowed under strict supervision, the standard dosing schedule is dangerous