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Once in the cytosol, Glu and Cys are combined into the dipeptide -glutamylcysteine (-GC) by the enzymatic activity of glutamatecysteine ligase (GCL), which requires ATP and Mg 2+ as co-substrates (Figure 2A) [15,16,17]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Hermanns H., Hollmann M.W., Stevens M.F., Lirk P., Brandenburger T., Piegeler T., Werdehausen R

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