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2.2 Mechanism of MM pathogenesis The pathogenesis of MM is a complex process leading to the replication of a malignant plasma cell clone that originates from the lymphoid B-cell lineage and develops after lineage commitment in the bone marrow ( Multiple mechanisms for MM cell dysregulation have been described, such as translocations of the Cyclin D1 gene with the IgH gene, specific Cyclin D gene amplifications, trisomies, and other cytogenetic events ( Dysregulation of cyclin D appears to be a necessary occurrence in the establishment of abnormal plasma cells

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The peptide bond itself is the same in all these chain types

249 Many studies investigating the effect of the KD on tumor metastasis indicate a metastasis-inhibiting effect of the KD

Environ Sci Pollut Res 28(33):4535345363 Jiang M, Zhang J (2002) Water stress-induced abscisic acid accumulation triggers the increased generation of reactive oxygen species and up-regulates the activities of antioxidant enzymes in maize leaves