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In T2D, therapeutic options, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, incretin-based drugs, and GLP-1 analogues, target -cell function, but not all patients are responsive and approximately 50% ultimately require daily insulin injections due to -cell exhaustion and death (149)

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doi: 10.1001/jamaoncol.2019.6650

Pro: Side effects are generally minimal and primarily center around the discomfort and unusual experience of using a suppository

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