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In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor 1) is a powerful research analogue engineered for superior receptor engagement and stability compared to native IGF-1

Results: The reduction of VAS was statistically significant ( P 0.005) with an average pre-PSLD-VAS of 6.75 0.63 and post-PSLD-VAS of 2.24 1.04

Additionally, hydroxocobalamin tends to be better tolerated by people who are sensitive to the methyl form of B12, including those with genetic variations such as MTHFR, making it a more universally suitable option

For children, Walsh modified his formula taking into account B12 absorption amounts found in children by Hjelt and Krasilnikoff (Hjelt, 1986)