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Cell Metab (2016) 23(6):9809.10.1016/j.cmet.2016.05.014 249 Guevara-AguirreJBalasubramanianPGuevara-AguirreMWeiMMadiaFChengCWet alGrowth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans